Epigenetic and Transgenerational Reprogramming of the Brain's Reward System: A Systematic Review and Clinical Counseling Guidelines.

Epigenetic and Transgenerational Reprogramming of the Brain's Reward System A Systematic R.

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2026 Volume - 2, Issue 1, Page 1-4

1. Dr Jaya Deshmukh, Director of Cognicare Neurobics, Demonstrator Anatomy Department Gandhi Medical College Bhopal , OIC Admission Cell DME, Directorate of Medical Education Satpura Bhawan Madhya Pradesh Bhopal. (Corresponding Author)

2. Dr. Vandana Sharma, Professor and Head, Department of Anatomy, Gandhi Medical College Hamidia Hospital, Bhopal.

3. Dr. Deepak Sharma, Assistant Professor, Department of Anatomy, Gandhi Medical College Hamidia Hospital, Bhopal.

Corresponding Author

Dr Jaya Deshmukh,

Director of Cognicare Neurobics,

Demonstrator Anatomy Department

Gandhi Medical College Bhopal ,

OIC Admission Cell DME, Directorate of Medical Education

Satpura Bhawan Madhya Pradesh Bhopal.

Abstract

Recent advances in neurobiology suggest that the brain's reward system—specifically the mesolimbic dopamine pathway—is not only shaped by individual experience but also by the experiences of ancestors. This systematic review explores the mechanisms of epigenetic inheritance (DNA methylation, histone modification, and non-coding RNAs) and how these biological "signatures" influence susceptibility to addiction, depression, and metabolic disorders. The review concludes with the Cognicare Neurobics Clinical Framework for counseling individuals with inherited neurobiological vulnerabilities.